In the current study, the development of mucoadhesive tablets for buccal\ndelivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes\nwith piroxicam and cyclodextrins (beta-cyclodextrin (beta-CD), methylated-beta-cyclodextrin (Me-beta-CD),\nand hydroxypropyl-beta-cyclodextrin (HP-beta-CD)) were prepared by the co-evaporation method. All\nformulations were characterized by means of differential scanning calorimetry, infrared spectroscopy\nand powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by\ndirect compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets\nwere conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa.\nThe results suggest that the rank order effect of cyclodextrins for the drug release was Me-beta-CD >\nHP-beta-CD > beta-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly\nincreased the transport of the drug compared to their free complexes. Finally, histological assessment\nrevealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.
Loading....